6-(5H)-Phenanthridinone, technical grade

Application

Reactant involved in: Synthesis of 5,6-dihydrophenanthridine sulfonamides Oxidative coupling with diphenylacetylene Direct copper acetate-catalyzed N-cyclopropylation of cyclic amidesReactant involved in the synthesis and/or pharmacological activity of biologically active molecules including: Potassium channel KV1.3 and IK-1 inhibitors HIV-1 integrase inhibitors

General description

6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.

Packaging

1 g in glass bottle